Domperidone: what it does and when doctors prescribe it

Ever been told domperidone might help with nausea or poor stomach emptying? That’s what it’s usually for. Domperidone helps speed up stomach emptying and eases nausea, vomiting, bloating, and fullness. It’s also used off-label to boost milk supply in breastfeeding people, but that use has extra risks to consider.

How people take domperidone

Typical adult dosing is 10 mg three times a day, taken about 15–30 minutes before meals. Many doctors advise not to exceed 30 mg per day because higher doses raise the chance of heart problems. Use the lowest effective dose for the shortest time needed. Children and people with liver problems need different dosing—follow your prescriber’s instructions exactly.

Side effects, interactions, and who should be careful

Common side effects are dry mouth, stomach cramps, headache, and dizziness. Domperidone can raise prolactin, the milk-producing hormone, which may cause breast swelling, unexpected milk production, or menstrual changes. Serious but less common risks involve the heart: domperidone can affect heart rhythm (QT prolongation) and, in rare cases, cause arrhythmias.

If you have heart disease, a history of irregular heartbeat, low potassium, or take other drugs that affect the QT interval, do not use domperidone unless your doctor checks you first. Strong CYP3A4 inhibitors — like ketoconazole, erythromycin, clarithromycin, some HIV drugs, and even grapefruit — can raise domperidone levels and increase heart risk. Tell your clinician about every medicine and supplement you take.

Older adults (over about 60) have a higher risk of heart side effects. Your doctor may ask for an ECG or blood tests before or during treatment if they think you’re at risk. If you feel racing heartbeats, fainting, severe dizziness, or chest pain, stop the drug and seek medical help.

Domperidone’s approval and rules vary by country. For example, it’s commonly available in many places but not approved as an oral drug everywhere. That means regulations, prescription requirements, and safety warnings differ. Always follow local guidance and your prescriber’s advice.

Thinking of buying domperidone online? Use a trusted, licensed pharmacy and keep your prescription. Avoid sites that sell without asking questions. Counterfeit or improperly dosed meds are a real danger.

If domperidone isn’t suitable, alternatives for nausea and gastroparesis include metoclopramide and ondansetron, but each has its own side effects. Talk with your healthcare provider about the best option for your situation—especially if you’re breastfeeding or have heart issues.

Quick checklist before starting domperidone: tell your doctor about heart disease, list all meds and supplements, ask if an ECG is needed, and confirm the right dose and duration. Small steps like these cut risks and help you get safe relief.