Bupropion Side Effects: What You Need to Know Before Taking It

When you start taking bupropion, a prescription antidepressant and smoking cessation aid also known by brand names like Wellbutrin and Zyban. It works differently than most SSRIs, targeting dopamine and norepinephrine instead of serotonin. That’s why it’s often chosen for people who struggle with weight gain, low energy, or sexual side effects from other meds. But it’s not without risks. About 1 in 5 people report side effects, and some can be serious enough to stop treatment.

Seizure risk, a rare but dangerous side effect tied to bupropion use is higher if you have a history of seizures, eating disorders, or are taking high doses. The FDA warns against doses above 450 mg per day. Dry mouth, a common complaint among users affects nearly half of people on bupropion, and insomnia, another frequent issue can make it hard to sleep, especially if taken later in the day. People switching from other antidepressants often notice increased anxiety or agitation in the first few weeks — this isn’t always a sign it’s not working, but it does need monitoring.

It’s not just about how you feel physically. Bupropion can interact with other drugs — like NSAIDs, common painkillers that can raise seizure risk when combined, or alcohol, which lowers the seizure threshold even more. Even something as simple as skipping meals or losing weight fast can increase your chances of a seizure. If you’re using bupropion to quit smoking, the stress of withdrawal might make side effects feel worse. That’s why timing and dose adjustments matter.

What you won’t see on most pharmacy labels is how often people stop taking it because of these side effects — not because it didn’t help, but because they didn’t know what to expect. The good news? Most side effects fade within a few weeks. Others can be managed with simple changes: taking it in the morning, drinking more water, avoiding caffeine after noon, or talking to your doctor about lowering the dose. You’re not alone if you’ve felt confused or frustrated by the side effects. Many people have been there, and the posts below give real advice from others who’ve navigated this path — from tracking symptoms to spotting warning signs before they turn serious.