Valacyclovir: Uses, Dosing, Side Effects & Safety
Valacyclovir is an antiviral many people use for cold sores, genital herpes, and shingles. Start it early during an outbreak and it can shorten symptoms and reduce pain. This guide gives plain, practical advice so you know what to expect and how to take it safely.
What valacyclovir does and when to use it
Valacyclovir turns into acyclovir in your body and stops the virus from multiplying. Doctors prescribe it for:
- Cold sores (herpes labialis), usually short-course treatment.
- Genital herpes, both initial outbreaks and recurrent episodes.
- Shingles (herpes zoster) to reduce nerve pain and speed healing.
Start treatment as soon as you notice symptoms—tingling, blisters, or new rash—for the best results. For preventing recurrent genital herpes, some people take lower daily doses as suppression therapy.
How to take valacyclovir
Dosages vary by condition. Common adult examples: initial genital herpes often 1 gram twice daily for 7–10 days; recurrent genital outbreaks might be 1 gram twice daily for 5 days or 500 mg twice daily for 3 days; shingles is often 1 gram three times daily for 7 days; cold sores can be a single-day high-dose option like 2 grams twice in one day. Follow your prescriber's exact instructions—these are typical ranges, not a substitute for medical advice.
Take pills with or without food. Drink plenty of water while on treatment—good hydration lowers the chance of kidney issues. If you have kidney disease, your doctor will adjust the dose.
Missed a dose? Take it as soon as you remember, unless the next dose is near. Don't double up doses to catch up.
Side effects are usually mild: headache, nausea, stomach pain, or dizziness. Serious problems can happen, especially with dehydration or existing kidney problems. Watch for sudden confusion, trouble breathing, severe rash, or marked decrease in urination—get medical help quickly if these occur.
Valacyclovir interacts with some drugs. Probenecid and other medicines that affect the kidneys can raise acyclovir levels. Combining with other nephrotoxic drugs increases kidney risk. If you take immunosuppressants, tell your doctor—your risk profile changes.
If you're pregnant, planning pregnancy, or breastfeeding, talk to your clinician. For many people, valacyclovir is used in pregnancy for recurrent genital herpes under doctor guidance, but decisions should be individualized.
Want to buy it online? Use only reputable pharmacies that require a valid prescription. Avoid sites that sell prescription drugs without asking for one. Check pharmacy reviews, look for clear contact info, and confirm secure payment and packaging.
Quick tips: start therapy early, stay hydrated, keep follow-up appointments, and alert your doctor about kidney problems or new symptoms. When used properly, valacyclovir is a reliable tool to control herpes viruses and cut the length and severity of outbreaks.

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